Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516852 | 0.87 | MAPT (0.40) | MAPTTDP1ALDH1A1POLBDRD2 | |
| SCHEMBL9517046 | 0.84 | MAPT (0.54) | MAPTSTAT3TDP1HTR1ACYP1A2 | |
| SCHEMBL9513853 | 0.84 | SMN1; SMN2 (0.49) | MAPTHTR1AALDH1A1DRD2HTR2A | |
| SCHEMBL9515163 | 0.84 | STAT3 (0.40) | MAPTSTAT3TDP1HTR1AGFER | |
| SCHEMBL9513786 | 0.83 | NPC1 (0.48) | STAT3HTR1AALDH1A1 | |
| SCHEMBL9596806 | 0.82 | MAPT (0.51) | MAPTSTAT3TDP1HTR1ACYP2C19 | |
| SCHEMBL9514704 | 0.82 | NPC1 (0.47) | STAT3HTR1AALDH1A1 | |
| SCHEMBL9517236 | 0.80 | HTR1A (0.43) | MAPTSTAT3TDP1HTR1AGFER | |
| SCHEMBL9516240 | 0.80 | NPC1 (0.48) | STAT3HTR1AALDH1A1 | |
| SCHEMBL9513686 | 0.78 | SIGMAR1 (0.47) | STAT3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227488-A | AZA SPIRO DECANE AND USE THEREOF IN TREATING CNS DISORDERS | NOVO NORDISK A/S (DK) | 1993-07-13 | — | — | US | disclosed |
| EP-0495826-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-07-29 | — | — | EP | disclosed |
| WO-1991004973-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-04-18 | — | — | WO | disclosed |