Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | PAM | P19021 | 1/20 | 0.38 |
| ▸ | PTAFR | P25105 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519681 | 1.00 | ALOX15 (0.44) | ALOX15TSHRCES2CES1GSK3B | |
| SCHEMBL9521627 | 0.84 | PAM (0.50) | ALOX15TSHRCES2CES1GSK3B | |
| SCHEMBL9520140 | 0.84 | PAM (0.50) | ALOX15TSHRCES2CES1GSK3B | |
| SCHEMBL9521054 | 0.83 | CES2 (0.41) | ALOX15CES2CES1MAPTALDH1A1 | |
| SCHEMBL9519790 | 0.83 | KMT2A (0.44) | CES2CES1GSK3BSRD5A2MAPT | |
| SCHEMBL9521278 | 0.81 | SMN1; SMN2 (0.46) | TSHRGSK3BERCC5FEN1MAPT | |
| SCHEMBL9519281 | 0.81 | ERCC5 (0.45) | ERCC5FEN1MAPTALDH1A1PAM | |
| SCHEMBL9520834 | 0.81 | ERCC5 (0.45) | ERCC5FEN1MAPTALDH1A1PAM | |
| SCHEMBL9521346 | 0.79 | CA1 (0.49) | CES2CES1GSK3BMAPTALDH1A1 | |
| SCHEMBL9421096 | 0.78 | BCL2L1 (0.41) | ALOX15TSHRCES2CES1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |