Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9521627 | 0.84 | PAM (0.50) | KMT2AALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL9520140 | 0.84 | PAM (0.50) | KMT2AALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL9519681 | 0.83 | ALOX15 (0.44) | ALDH1A1LMNACES2CES1MAPT | |
| SCHEMBL9522078 | 0.83 | ALOX15 (0.44) | ALDH1A1LMNACES2CES1MAPT | |
| SCHEMBL9521054 | 0.83 | CES2 (0.41) | ALDH1A1CES2CES1NPC1RAB9A | |
| SCHEMBL9521346 | 0.82 | CA1 (0.49) | ALDH1A1SMN1; SMN2HPGDCES2CES1 | |
| SCHEMBL9521278 | 0.81 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2LMNAHTTHPGD | |
| SCHEMBL8398701 | 0.80 | ALDH1A1 (0.52) | KMT2AALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL9523136 | 0.79 | CES2 (0.53) | KMT2AALDH1A1PKMMEN1CES2 | |
| SCHEMBL9522407 | 0.79 | CES2 (0.53) | KMT2AALDH1A1PKMMEN1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |