SCHEMBL9522037

SCHEMBL9522037

O=C(Cl)c1ccccc1Nc1cccc(C(F)(F)F)c1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
YAP1 P46937 1/20 0.74
TEAD4 Q15561 1/20 0.74
TEAD2 Q15562 1/20 0.74
RXFP1 Q9HBX9 8/20 0.73
MPO P05164 3/20 0.62
LMNA P02545 1/20 0.59
CYP1A2 P05177 1/20 0.59
CYP2C9 P11712 1/20 0.59
CYP2C19 P33261 1/20 0.59
ALDH1A1 P00352 1/20 0.58
GAA P10253 1/20 0.58
MAPT P10636 1/20 0.58
RAB9A P51151 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
GRIK1 P39086 1/20 0.56
AKR1C3 P42330 1/20 0.56
AKR1C2 P52895 1/20 0.56
AURKA O14965 1/20 0.55
MAPK8 P45983 1/20 0.55
KDR P35968 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flufenamic Acid SCHEMBL17497 0.87 RXFP1 (0.75) YAP1TEAD4TEAD2RXFP1MPO
Flufenamic Acid SCHEMBL29356958 0.87 RXFP1 (0.75) YAP1TEAD4TEAD2RXFP1MPO
SCHEMBL9268782 0.86 RXFP1 (0.78) YAP1TEAD4TEAD2RXFP1MPO
Flufenamic Acid SCHEMBL9845499 0.86 RXFP1 (0.73) YAP1TEAD4TEAD2RXFP1MPO
Flufenamic Acid SCHEMBL11524554 0.86 RXFP1 (0.73) YAP1TEAD4TEAD2RXFP1MPO
SCHEMBL9270625 0.86 RXFP1 (0.73) YAP1TEAD4TEAD2RXFP1MPO
SCHEMBL12851592 0.86 RXFP1 (0.78) YAP1TEAD4TEAD2RXFP1MPO
SCHEMBL22731881 0.85 YAP1 (1.00) YAP1TEAD4TEAD2RXFP1MPO
SCHEMBL30197844 0.85 YAP1 (1.00) YAP1TEAD4TEAD2RXFP1MPO
Flufenamic Acid SCHEMBL11524550 0.84 RXFP1 (0.71) YAP1TEAD4TEAD2RXFP1MPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0254354-B1 PHARMACEUTICALLY USEFUL DERIVATIVES OF THIAZOLIDINE-4-CARBOXYLIC ACID ZAMBON S.p.A. (IT) 1993-03-31 EP disclosed
US-4840936-A ANTIFLAMMATORY, ANALGESIC AGENT TO PREVENT ARRHYTHMIAS ZAMBON S.P.A. (IT) 1989-06-20 US disclosed
EP-0254354-A1 Pharmaceutically useful derivatives of thiazolidine-4-carboxylic acid ZAMBON S.p.A. (IT) 1988-01-27 EP disclosed
EP-0095641-B1 QUINAZOLINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS Troponwerke GmbH & Co. KG (DE) 1987-07-29 EP disclosed
US-4546106-A ANTIARTHRITIC AGENTS MERCK & CO., INC. (US) 1985-10-08 US disclosed
US-4539402-A ANTIINFLAMMATORY AGENTS TROPONWERKE GMBH & CO. (DE) 1985-09-03 US disclosed
EP-0095641-A1 Quinazolinone derivatives, process for their preparation and their use in medicaments Troponwerke GmbH & Co. KG (DE) 1983-12-07 EP disclosed
US-4355034-A Ethenyl derivatives of mercaptoalkylpyridines as anti-inflammatory agents MERCK & CO., INC. (US) 1982-10-19 US disclosed
US-4217352-A ANTIARTHRITIC AGENT MERCK & CO., INC. (US) 1980-08-12 US disclosed
US-4212976-A ANTIARTHRITIC AGENTS MERCK & CO., INC. (US) 1980-07-15 US disclosed
US-4144342-A ANTIARTHRITIC AND ANTIINFLAMMATORY AGENTS MERCK & CO., INC. (US) 1979-03-13 US disclosed
US-4061759-A ANTIINFLAMMATORY, ARTHRITIS MERCK & CO., INC. (US) 1977-12-06 US disclosed
US-4057637-A RHEUMATOID ARTHRITIS MERCK & CO., INC. (US) 1977-11-08 US disclosed
US-3971797-A ANTIARTHRITIC MERCK & CO., INC. (US) 1976-07-27 US disclosed