Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9523476 | 0.90 | MAPT (0.47) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL9525596 | 0.86 | POLB (0.50) | POLBHTTMEN1KMT2AMAPT | |
| SCHEMBL9524492 | 0.83 | KCNMA1 (0.46) | POLBHTTMEN1KMT2AMAPT | |
| SCHEMBL9524620 | 0.81 | P2RX1 (0.52) | POLBHTTMEN1KMT2AMAPT | |
| SCHEMBL9524522 | 0.81 | ALDH1A1 (0.51) | POLBHTTMEN1KMT2AMAPT | |
| SCHEMBL9524344 | 0.80 | TMPRSS4 (0.51) | POLBHTTMEN1KMT2ANPC1 | |
| SCHEMBL9524532 | 0.80 | S1PR4 (0.44) | POLBHTTMEN1KMT2AMAPT | |
| SCHEMBL9525872 | 0.79 | P2RX1 (0.50) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL9525061 | 0.79 | RAB9A (0.51) | POLBMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL9524888 | 0.78 | MEN1 (0.49) | POLBMEN1KMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |