Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524652 | 0.84 | KDM4E (0.35) | KDM4ETRPV1 | |
| SCHEMBL9524833 | 0.82 | TLR3 (0.37) | — | |
| SCHEMBL9524525 | 0.77 | RAB9A (0.36) | KDM4E | |
| SCHEMBL9524946 | 0.74 | HTR1A (0.34) | TRPV1 | |
| SCHEMBL9525763 | 0.74 | ABCC9 (0.38) | — | |
| SCHEMBL9524585 | 0.73 | ALOX5 (0.38) | KCNA5KDM4ETRPV1 | |
| SCHEMBL9527411 | 0.73 | BRD4 (0.37) | KDM4ETRPV1 | |
| SCHEMBL9524905 | 0.71 | DRD4 (0.33) | TRPV1 | |
| SCHEMBL9525115 | 0.70 | DRD4 (0.33) | KCNA5TRPV1 | |
| SCHEMBL9523970 | 0.70 | DRD4 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | claimed |
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |