Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524902 | 0.91 | ESR1 (0.42) | BRD4SMN1; SMN2KDM4ECTNNB1WNT3A | |
| SCHEMBL9523546 | 0.90 | TGFBR1 (0.39) | BRD4SMN1; SMN2KDM4ECTNNB1WNT3A | |
| SCHEMBL9527561 | 0.89 | ABCC9 (0.39) | BRD4SMN1; SMN2CTNNB1WNT3A | |
| SCHEMBL9524954 | 0.88 | BRD4 (0.35) | BRD4SMN1; SMN2KDM4ECTNNB1WNT3A | |
| SCHEMBL9524371 | 0.88 | KDM4E (0.42) | BRD4SMN1; SMN2KDM4E | |
| SCHEMBL9628082 | 0.86 | ABCC9 (0.34) | BRD4SMN1; SMN2CTNNB1WNT3ATRPV1 | |
| SCHEMBL9627698 | 0.84 | BRD4 (0.37) | BRD4SMN1; SMN2CTNNB1WNT3ATRPV1 | |
| SCHEMBL9628191 | 0.84 | ABCC9 (0.33) | BRD4SMN1; SMN2CTNNB1WNT3ATRPV1 | |
| SCHEMBL9527983 | 0.84 | TLR3 (0.40) | SMN1; SMN2KDM4E | |
| SCHEMBL9524525 | 0.82 | RAB9A (0.36) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1030582-A | 1-benzopyran derivatives | HOFFMANN LA ROCHE (CH) | 1989-01-25 | — | — | CN | claimed |
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |
| EP-0298452-A2 | 2H-1-benzopyrane derivatives substituted in position 4 by aryl or N-heteroaryl | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-11 | — | — | EP | disclosed |