Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TNKS | O95271 | 3/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527561 | 0.93 | ABCC9 (0.39) | ABCC9BRD4SMN1; SMN2ESR1PABPC1 | |
| SCHEMBL9628191 | 0.92 | ABCC9 (0.33) | ABCC9BRD4SMN1; SMN2ESR1PABPC1 | |
| SCHEMBL9627698 | 0.88 | BRD4 (0.37) | BRD4SMN1; SMN2ESR1PABPC1PLK1 | |
| SCHEMBL9527983 | 0.87 | TLR3 (0.40) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9524902 | 0.86 | ESR1 (0.42) | BRD4SMN1; SMN2ESR1PABPC1PLK1 | |
| SCHEMBL9527411 | 0.86 | BRD4 (0.37) | BRD4SMN1; SMN2CTNNB1WNT3ATRPV1 | |
| SCHEMBL9523546 | 0.85 | TGFBR1 (0.39) | BRD4SMN1; SMN2CTNNB1WNT3ATGFBR1 | |
| SCHEMBL9524954 | 0.83 | BRD4 (0.35) | BRD4SMN1; SMN2ESR1PABPC1PLK1 | |
| SCHEMBL9524371 | 0.83 | KDM4E (0.42) | BRD4SMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL9524908 | 0.79 | MAPT (0.40) | SMN1; SMN2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |