Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.35 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527561 | 0.84 | ABCC9 (0.39) | MAPTALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL9524902 | 0.84 | ESR1 (0.42) | SMN1; SMN2KDM4EMEN1KMT2AESR1 | |
| SCHEMBL8795216 | 0.82 | TRPV1 (0.41) | MAPTALDH1A1HTTTAAR1CYP3A4 | |
| SCHEMBL9527411 | 0.81 | BRD4 (0.37) | SMN1; SMN2KDM4E | |
| SCHEMBL9524371 | 0.81 | KDM4E (0.42) | MAPTALDH1A1HTTTAAR1SMN1; SMN2 | |
| SCHEMBL9523546 | 0.81 | TGFBR1 (0.39) | MAPTALDH1A1SMN1; SMN2TSHRKDM4E | |
| SCHEMBL9628082 | 0.79 | ABCC9 (0.34) | SMN1; SMN2ESR1 | |
| SCHEMBL9524954 | 0.79 | BRD4 (0.35) | ALDH1A1SMN1; SMN2KDM4EESR1CYP3A4 | |
| SCHEMBL9525760 | 0.78 | TRPM5 (0.42) | HTTSMN1; SMN2KCNE1KCNQ1LMNA | |
| SCHEMBL9524374 | 0.78 | HTR2B (0.35) | MAPTSMN1; SMN2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |
| EP-0298452-A2 | 2H-1-benzopyrane derivatives substituted in position 4 by aryl or N-heteroaryl | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-11 | — | — | EP | disclosed |