Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069849 | 0.79 | F11 (0.39) | ALDH1A1KDM4EF11LMNANPC1 | |
| SCHEMBL9526288 | 0.78 | F11 (0.36) | ALDH1A1KDM4EF11L3MBTL1LMNA | |
| SCHEMBL9525213 | 0.78 | ALDH1A1 (0.44) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL22478641 | 0.77 | DGAT1 (0.37) | MAPK14MAPK13MAPK12MAPK11F11 | |
| SCHEMBL26965221 | 0.76 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11MAPK10 | |
| SCHEMBL29429962 | 0.76 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11MAPK10 | |
| SCHEMBL22470948 | 0.76 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11MAPK10 | |
| SCHEMBL9737058 | 0.75 | F11 (0.37) | ALDH1A1KDM4EF11NPC1 | |
| SCHEMBL9737053 | 0.75 | F11 (0.37) | ALDH1A1KDM4EF11NPC1 | |
| SCHEMBL2846531 | 0.75 | FAAH (0.43) | KDM4EF11PTGS1PTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993001183-A1 | IMIDAZOLE DERIVATIVE AS ACAT INHIBITOR | RHONE-POULENC RORER LIMITED (GB) | 1993-01-21 | — | — | WO | disclosed |
| WO-1993001184-A1 | IMIDAZOLES INHIBITORS AS ACAT AND THROMBOXANE TXA2 | RHONE-POULENC RORER LIMITED (GB) | 1993-01-21 | — | — | WO | disclosed |
| EP-0523941-A1 | Imidazoles as ACAT inhibitor | RHONE-POULENC RORER LIMITED (GB) | 1993-01-20 | — | — | EP | disclosed |
| EP-0522887-A1 | Imidazoles as ACAT- and thromboxane TxA2 inhibitors | RHONE-POULENC RORER LIMITED (GB) | 1993-01-13 | — | — | EP | disclosed |