Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9702558 | 0.80 | ALDH1A1 (0.41) | KDM4EALDH1A1GLAL3MBTL1GAA | |
| SCHEMBL7371784 | 0.79 | KDM4E (0.60) | KDM4EALDH1A1GLAL3MBTL1GAA | |
| SCHEMBL7646365 | 0.78 | PDE5A (0.50) | KDM4EALDH1A1GLAL3MBTL1GAA | |
| SCHEMBL9529353 | 0.75 | CYP2C9 (0.34) | KDM4EALDH1A1PDE5AMAPTHSD17B10 | |
| SCHEMBL9526090 | 0.73 | KDM4E (0.74) | KDM4EALDH1A1GLAL3MBTL1GAA | |
| SCHEMBL9526882 | 0.73 | ALDH1A1 (0.44) | KDM4EALDH1A1GLAL3MBTL1GAA | |
| SCHEMBL9702581 | 0.73 | ALDH1A1 (0.44) | KDM4EALDH1A1GLAL3MBTL1GAA | |
| SCHEMBL9701860 | 0.72 | KDM4E (0.55) | KDM4EALDH1A1GLAL3MBTL1GAA | |
| SCHEMBL9701620 | 0.71 | KDM4E (0.57) | KDM4EALDH1A1GLAL3MBTL1GAA | |
| SCHEMBL7647544 | 0.71 | ALDH1A1 (0.54) | KDM4EALDH1A1GLAL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550576-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992006085-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |