Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 8/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526989 | 0.88 | ADRA1A (0.55) | HTR1AADRA1BADRA1DADRA1AHTR7 | |
| SCHEMBL27263634 | 0.87 | HTR1A (0.47) | HTR1AADRA1BADRA1DADRA1AHTR7 | |
| SCHEMBL9527377 | 0.87 | ADRA1A (0.54) | HTR1AADRA1BADRA1DADRA1ABRD4 | |
| SCHEMBL9528533 | 0.85 | ADRA1A (0.71) | HTR1AADRA1BADRA1DADRA1A | |
| SCHEMBL9531491 | 0.84 | BRD4 (0.51) | HTR1AADRA1BADRA1DADRA1ABRD4 | |
| SCHEMBL9528344 | 0.84 | ADRA1D (0.48) | HTR1AADRA1BADRA1DADRA1AHTR7 | |
| SCHEMBL9527664 | 0.83 | HTR1A (0.58) | HTR1AADRA1BADRA1DADRA1AHTR7 | |
| SCHEMBL9527503 | 0.81 | ADRA1A (0.57) | HTR1AADRA1BADRA1DADRA1AHTR7 | |
| SCHEMBL9528463 | 0.81 | GAA (0.45) | HTR1AADRA1BADRA1DADRA1AHTR7 | |
| SCHEMBL9526815 | 0.81 | HTR1A (0.47) | HTR1AADRA1BADRA1DADRA1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |