Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 5/20 | 0.54 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.54 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529034 | 0.94 | ADRA1A (0.56) | ADRA1AHTR1AADRA1DADRA1BDRD2 | |
| SCHEMBL9526989 | 0.88 | ADRA1A (0.55) | ADRA1AHTR1AADRA1DADRA1BDRD2 | |
| SCHEMBL27263628 | 0.87 | ADRA1A (0.47) | ADRA1AHTR1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527118 | 0.87 | HTR1A (0.52) | ADRA1AHTR1AADRA1DADRA1BBRD4 | |
| SCHEMBL9528533 | 0.85 | ADRA1A (0.71) | ADRA1AHTR1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527005 | 0.84 | ADRA1A (0.52) | ADRA1AHTR1AADRA1DADRA1BDRD2 | |
| SCHEMBL9528344 | 0.84 | ADRA1D (0.48) | ADRA1AHTR1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527664 | 0.83 | HTR1A (0.58) | ADRA1AHTR1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527037 | 0.82 | DRD2 (0.49) | ADRA1AHTR1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527503 | 0.81 | ADRA1A (0.57) | ADRA1AHTR1AADRA1DADRA1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |