Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 5/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.48 |
| ▸ | HTR1A | P08908 | 5/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527037 | 0.88 | DRD2 (0.49) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9526989 | 0.85 | ADRA1A (0.55) | ADRA1DADRA1AADRA1BHTR1AHTR7 | |
| SCHEMBL9526815 | 0.85 | HTR1A (0.47) | ADRA1DADRA1AADRA1BHTR1AHTR7 | |
| SCHEMBL9527138 | 0.84 | ATM (0.54) | ADRA1AHTR7DRD2SIGMAR1 | |
| SCHEMBL9527118 | 0.84 | HTR1A (0.52) | ADRA1DADRA1AADRA1BHTR1AHTR7 | |
| SCHEMBL9527377 | 0.84 | ADRA1A (0.54) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9528427 | 0.83 | HTR1A (0.46) | ADRA1DADRA1AADRA1BHTR1AHTR7 | |
| SCHEMBL9531572 | 0.82 | KAT2B (0.58) | ADRA1DADRA1AADRA1BDRD2HTR2A | |
| SCHEMBL9528533 | 0.82 | ADRA1A (0.71) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9528837 | 0.81 | DRD2 (0.48) | HTR1AHTR7DRD2HTR2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |