Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 8/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 8/20 | 0.43 |
| ▸ | HTR2C | P28335 | 5/20 | 0.43 |
| ▸ | HTR1D | P28221 | 4/20 | 0.43 |
| ▸ | HTR2B | P41595 | 4/20 | 0.43 |
| ▸ | HTR5A | P47898 | 4/20 | 0.43 |
| ▸ | HTR6 | P50406 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27263078 | 0.86 | HTR1A (0.41) | GAAALDH1A1DRD4ADRA1BHTR1A | |
| SCHEMBL9527044 | 0.84 | HTR1A (0.63) | DRD4ADRA1BHTR1AADRA1DADRA1A | |
| SCHEMBL6586501 | 0.83 | HTR7 (0.48) | HTR1AHTR7HTR6HTR2ADRD2 | |
| SCHEMBL9527118 | 0.81 | HTR1A (0.52) | GAAADRA1BHTR1AADRA1DGFER | |
| SCHEMBL10431149 | 0.78 | HTR7 (0.43) | GAAADRA1BHTR1AADRA1DHTR7 | |
| SCHEMBL9528402 | 0.78 | HTR1A (0.61) | ADRA1BHTR1AADRA1DHTR7HTR2B | |
| SCHEMBL9527740 | 0.77 | DRD2 (0.64) | DRD4ADRA1BHTR1AADRA1DHTR7 | |
| SCHEMBL9527347 | 0.76 | HTR1A (0.52) | ADRA1BHTR1AADRA1DHTR7HTR6 | |
| SCHEMBL4616926 | 0.75 | ADRA1A (0.62) | GAAHTR1AGFERADRA1ADRD2 | |
| SCHEMBL11447503 | 0.74 | HTR1A (0.51) | GAAALDH1A1DRD4HTR1AGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |