Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530968 | 0.89 | DRD2 (0.52) | HTR7ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL9527885 | 0.85 | ADRA1B (0.49) | HTR7ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL9529080 | 0.84 | POLB (0.48) | HTR7HTR1ADRD2KCNH2 | |
| SCHEMBL9528180 | 0.84 | ADRA1B (0.46) | HTR7ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL9527068 | 0.84 | HTR7 (0.40) | HTR7ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL9529414 | 0.83 | ALOX15 (0.50) | HTR7HTR1ADRD2TP53 | |
| SCHEMBL9527896 | 0.82 | HTR1A (0.62) | HTR7ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL9526846 | 0.81 | ADRA1D (0.56) | HTR7ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL27263872 | 0.80 | DRD2 (0.47) | HTR7HTR1ADRD2TP53 | |
| SCHEMBL5926097 | 0.80 | HTR7 (0.56) | HTR7HTR1ADRD2KCNH2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |