Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | FAAH | O00519 | 3/20 | 0.49 |
| ▸ | MGLL | Q99685 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15317641 | 0.79 | SMN1; SMN2 (0.61) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL9527348 | 0.78 | TDP1 (0.56) | ALDH1A1FAAHMGLLSMN1; SMN2NPC1 | |
| SCHEMBL9529297 | 0.78 | ALDH1A1 (0.71) | ALDH1A1FAAHMGLLSMN1; SMN2NPC1 | |
| SCHEMBL9871967 | 0.78 | FAAH (0.57) | ALDH1A1FAAHMGLLSIGMAR1SMN1; SMN2 | |
| SCHEMBL11403715 | 0.74 | L3MBTL1 (0.64) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL11486106 | 0.72 | SIGMAR1 (0.47) | ALDH1A1SIGMAR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL11485737 | 0.72 | SIGMAR1 (0.47) | ALDH1A1SIGMAR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL11510766 | 0.71 | NR1H4 (0.47) | ALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL11723963 | 0.71 | SMN1; SMN2 (0.51) | ALDH1A1SIGMAR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL270997 | 0.70 | HRH3 (0.69) | ALDH1A1SIGMAR1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252474-B1 | HYDRAZINE DERIVATIVES | AMERICAN CYANAMID COMPANY (US) | 1993-04-21 | — | — | EP | disclosed |
| US-4916237-A | Substituted 1,2,3-thiadiazole-4-thiolates | AMERICAN CYANAMID COMPANY (US) | 1990-04-10 | — | — | US | disclosed |
| US-4803280-A | Substituted 1,2,3-thia-diazole-4-thiolates | AMERICAN CYANAMID COMPANY (US) | 1989-02-07 | — | — | US | disclosed |