Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 4/20 | 0.34 |
| ▸ | CTSK | P43235 | 5/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | CTSH | P09668 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.31 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL9529745 | 0.93 | METAP1 (0.32) | METAP1 | |
| Dimethylamine SCHEMBL9528124 | 0.93 | CTSK (0.32) | ALDH1A1KDM4EMETAP1CTSKCTSL | |
| SCHEMBL10368162 | 0.84 | METAP1 (0.37) | ALDH1A1KDM4EMETAP1POLBLMNA | |
| SCHEMBL9528551 | 0.81 | POLB (0.38) | ALDH1A1KDM4EMETAP1CTSKPOLB | |
| SCHEMBL9528238 | 0.80 | POLB (0.37) | ALDH1A1KDM4EMETAP1CTSKPOLB | |
| SCHEMBL9527618 | 0.80 | PKM (0.38) | ALDH1A1KDM4EMETAP1POLBLMNA | |
| SCHEMBL9528360 | 0.80 | RAB9A (0.36) | ALDH1A1KDM4EMETAP1CTSKPOLB | |
| SCHEMBL9528699 | 0.79 | HTT (0.39) | ALDH1A1KDM4EPOLBMAPTTSHR | |
| SCHEMBL9528690 | 0.79 | NPSR1 (0.38) | ALDH1A1KDM4EMETAP1POLBLMNA | |
| SCHEMBL9529639 | 0.79 | ALDH1A1 (0.39) | ALDH1A1KDM4EMETAP1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | claimed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | claimed |
| EP-0319170-A2 | Acyl derivatives of hydroxy pyrimidines | PFIZER INC. (US) | 1989-06-07 | — | — | EP | claimed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | disclosed |
| WO-1989005295-A1 | ACYL DERIVATIVES OF HYDROXYPYRIMIDINES | PFIZER INC. (US) | 1989-06-15 | — | — | WO | disclosed |