SCHEMBL9529177

SCHEMBL9529177

Clc1ccc(OCCON=C(c2ccccc2)c2ccncc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C9 P11712 1/20 0.52
HPGD P15428 1/20 0.52
CYP2C19 P33261 1/20 0.52
NPSR1 Q6W5P4 1/20 0.45
MAPT P10636 1/20 0.44
MAPK1 P28482 1/20 0.44
TBXA2R P21731 12/20 0.44
PSEN1 P49768 1/20 0.44
PSEN2 P49810 1/20 0.44
APH1B Q8WW43 1/20 0.44
NCSTN Q92542 1/20 0.44
APH1A Q96BI3 1/20 0.44
PSENEN Q9NZ42 1/20 0.44
TBXAS1 P24557 5/20 0.43
LMNA P02545 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9527590 0.90 ALDH1A1 (0.58) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL9529153 0.89 TBXAS1 (0.53) ALDH1A1SMN1; SMN2MAPTTBXA2RPSEN1
SCHEMBL10406688 0.87 ALDH1A1 (0.60) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL9528785 0.85 KDM4E (0.55) ALDH1A1SMN1; SMN2HPGDNPSR1MAPT
SCHEMBL9528177 0.80 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL9530560 0.78 TBXAS1 (0.58) ALDH1A1MAPTTBXA2RTBXAS1
SCHEMBL9529764 0.76 TBXAS1 (0.56) ALDH1A1SMN1; SMN2CYP1A2CYP2C9CYP2C19
SCHEMBL9529604 0.76 TBXA2R (0.52) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL9529159 0.74 TBXA2R (0.50) ALDH1A1SMN1; SMN2HPGDNPSR1MAPT
SCHEMBL9529174 0.73 LTA4H (0.39) ALDH1A1SMN1; SMN2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0366006-B1 PYRIDYLKETOXIME ETHER COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING IT KAKEN PHARMACEUTICAL CO., LTD. (JP) 1993-09-29 EP disclosed
US-4971985-A ANTIISCHEMIC AGENTS, CARDIOVASCULAR DISORDERS KAKEN PHARMACEUTICAL CO., LTD. (JP) 1990-11-20 US disclosed
EP-0366006-A1 Pyridylketoxime ether compound and pharmaceutical composition containing it KAKEN PHARMACEUTICAL CO., LTD. (JP) 1990-05-02 EP disclosed