Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 5/20 | 0.59 |
| ▸ | BRD4 | O60885 | 5/20 | 0.51 |
| ▸ | BRD9 | Q9H8M2 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | BPTF | Q12830 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526962 | 0.94 | KAT2B (0.57) | KAT2BBRD4BRD9HTR1ADRD2 | |
| SCHEMBL9528850 | 0.85 | BPTF (0.49) | KAT2BHTR1ADRD2DRD4HTR2A | |
| SCHEMBL9526815 | 0.85 | HTR1A (0.47) | HTR1ADRD4HTR7ADRA1DADRA1A | |
| SCHEMBL9531572 | 0.85 | KAT2B (0.58) | KAT2BBRD4BRD9DRD2HTR2A | |
| SCHEMBL6184467 | 0.82 | PKM (0.52) | HTR1ADRD2DRD4HTR2AHTR2C | |
| SCHEMBL9527047 | 0.82 | BRD4 (0.57) | KAT2BBRD4BRD9HTR1ADRD2 | |
| SCHEMBL9531491 | 0.81 | BRD4 (0.51) | KAT2BBRD4BRD9HTR1ABPTF | |
| SCHEMBL9527005 | 0.81 | ADRA1A (0.52) | KAT2BBRD4BRD9HTR1ADRD2 | |
| SCHEMBL9527544 | 0.81 | KAT2B (0.56) | KAT2BBRD4BRD9BPTF | |
| SCHEMBL9526946 | 0.80 | HTR1A (0.53) | KAT2BBRD4BRD9HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |