Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9528143 | 0.92 | CYP1A2 (0.42) | CYP1A2CYP3A4CYP2D6CYP1A1CYP1B1 | |
| SCHEMBL9529772 | 0.89 | SGMS2 (0.47) | KMT2AMAPTSMN1; SMN2HTR1ADRD2 | |
| SCHEMBL9527826 | 0.87 | MAPK1 (0.53) | CYP1A2CYP3A4CYP2D6CYP1A1CYP1B1 | |
| SCHEMBL10407862 | 0.86 | HTR1A (0.46) | CYP1A2CYP3A4CYP2D6CYP1A1CYP1B1 | |
| SCHEMBL9532132 | 0.85 | KMT2A (0.51) | KMT2AHTR1ADRD2USP2ALDH1A1 | |
| SCHEMBL9529147 | 0.84 | NOTUM (0.44) | KMT2AMAPTMEN1LMNASMN1; SMN2 | |
| SCHEMBL9528361 | 0.82 | ALDH1A1 (0.50) | CYP1A2CYP2D6KMT2AMAPTMEN1 | |
| SCHEMBL9528579 | 0.82 | ALDH1A1 (0.53) | KMT2AMAPTMEN1LMNASMN1; SMN2 | |
| SCHEMBL10407323 | 0.82 | ABCB1 (0.61) | CYP1A2CYP3A4CYP2D6CYP1A1CYP1B1 | |
| SCHEMBL9529759 | 0.81 | KMT2A (0.43) | CYP1A2KMT2AMAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0366006-B1 | PYRIDYLKETOXIME ETHER COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING IT | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1993-09-29 | — | — | EP | disclosed |
| US-4971985-A | ANTIISCHEMIC AGENTS, CARDIOVASCULAR DISORDERS | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1990-11-20 | — | — | US | disclosed |
| EP-0366006-A1 | Pyridylketoxime ether compound and pharmaceutical composition containing it | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1990-05-02 | — | — | EP | disclosed |