⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531226 | 0.95 | AGTR1 (0.35) | — | |
| SCHEMBL9590924 | 0.82 | AGTR2 (0.38) | — | |
| SCHEMBL9532111 | 0.80 | AGTR2 (0.42) | — | |
| SCHEMBL9590665 | 0.79 | PDE4A (0.39) | — | |
| SCHEMBL9592014 | 0.78 | GSK3B (0.46) | — | |
| SCHEMBL9592404 | 0.76 | NPC1 (0.45) | — | |
| SCHEMBL9592290 | 0.76 | — | — | |
| SCHEMBL9532741 | 0.75 | PPARG (0.43) | — | |
| SCHEMBL9533888 | 0.74 | PTPN1 (0.45) | — | |
| SCHEMBL9590852 | 0.74 | PDE4A (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | claimed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | claimed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | claimed |
| EP-0307084-B1 | Substituted thieno(2,3-b)thiophene-2-sulfonamides as antiglaucoma agents | MERCK & CO INC (US) | 1993-12-15 | — | — | EP | disclosed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | disclosed |
| EP-0307084-A1 | Substituted thieno(2,3-b)thiophene-2-sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1989-03-15 | — | — | EP | disclosed |