Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR3 | O15455 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531520 | 0.84 | HIF1A (0.46) | TLR3PTGS2CTDSP1L3MBTL1DRD2 | |
| SCHEMBL9534866 | 0.77 | PTGS2 (0.39) | TLR3PTGS2CTDSP1L3MBTL1LMNA | |
| SCHEMBL9531441 | 0.76 | PTGS2 (0.42) | PTGS2CTDSP1L3MBTL1LMNAALDH1A1 | |
| SCHEMBL9632320 | 0.74 | TLR3 (0.41) | TLR3PTGS2CTDSP1L3MBTL1LMNA | |
| SCHEMBL9632014 | 0.74 | TLR3 (0.45) | TLR3PTGS2LMNATLR9TLR8 | |
| SCHEMBL6987818 | 0.73 | TLR3 (0.46) | TLR3PTGS2TLR9TLR8ALDH1A1 | |
| SCHEMBL8340736 | 0.72 | PTGS2 (0.39) | PTGS2CTDSP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL9531990 | 0.71 | ALDH1A1 (0.52) | PTGS2CTDSP1L3MBTL1DRD2DRD4 | |
| SCHEMBL9531634 | 0.70 | TLR3 (0.47) | TLR3PTGS2DRD2DRD4DRD3 | |
| SCHEMBL2558890 | 0.69 | PTGS1 (0.46) | PTGS2LMNAMAPTHIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277836-B1 | THIAZOLIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE | Sankyo Company Limited (JP) | 1993-06-02 | — | — | EP | disclosed |
| US-4873255-A | REDUCE BLOOD GLUCOSE AND BLOOD LIPID LEVELS | SANKYO COMPANY LIMITED (JP) | 1989-10-10 | — | — | US | disclosed |
| EP-0277836-A1 | Thiazolidinone derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1988-08-10 | — | — | EP | disclosed |