SCHEMBL9535335

SCHEMBL9535335

CC(=O)c1ccc(N)c(Sc2ccccc2Cl)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.53
POLB P06746 2/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
PDE7A Q13946 3/20 0.45
USP7 Q93009 1/20 0.42
ALDH1A1 P00352 7/20 0.40
KDM4E B2RXH2 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
PRKCI P41743 1/20 0.40
HPGD P15428 2/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
RECQL P46063 1/20 0.38
LMNA P02545 1/20 0.38
RAB9A P51151 1/20 0.38
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
HDAC2 Q92769 1/20 0.37
PKM P14618 1/20 0.37
CREBBP Q92793 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5830744 0.84 MAPT (0.48) MAPTPOLBL3MBTL1PDE7AUSP7
SCHEMBL9535361 0.84 ITGB2 (0.50) MAPTPOLBL3MBTL1PDE7AUSP7
SCHEMBL9537872 0.80 HPGD (0.59) MAPTPOLBL3MBTL1PDE7AALDH1A1
SCHEMBL9535339 0.80 L3MBTL1 (0.51) MAPTPOLBL3MBTL1ALDH1A1MEN1
SCHEMBL9538031 0.79 MAPT (0.50) MAPTPOLBL3MBTL1ALDH1A1KDM4E
SCHEMBL9538378 0.78 USP7 (0.59) MAPTPOLBL3MBTL1PDE7AUSP7
SCHEMBL9536561 0.78 MAPT (0.57) MAPTPOLBL3MBTL1PDE7AUSP7
SCHEMBL13239476 0.76 HPGD (0.62) MAPTL3MBTL1USP7ALDH1A1KDM4E
SCHEMBL9539520 0.76 ALDH1A1 (0.45) MAPTPOLBL3MBTL1USP7ALDH1A1
SCHEMBL9534492 0.74 ALDH1A1 (0.48) MAPTPOLBL3MBTL1PDE7AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0292979-B1 NEW ALKANESULFONANILIDE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-07-21 EP disclosed
US-5034417-A Antiinflammatory agents or analgesics FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1991-07-23 US disclosed