Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,2-Dichlorobenzene SCHEMBL27771165 | 0.81 | HSD11B1 (0.43) | HSD11B1TRPA1TRPM8TRPV1BACE1 | |
| SCHEMBL8981693 | 0.76 | TRPA1 (0.46) | HSD11B1TRPA1TRPM8TRPV1BACE1 | |
| SCHEMBL28008343 | 0.73 | NOTUM (0.46) | HSD11B1TRPA1BACE1NOTUM | |
| SCHEMBL397945 | 0.73 | ALDH1A1 (0.59) | HSD11B1TRPA1BACE1NOTUM | |
| SCHEMBL9535483 | 0.72 | IKBKB (0.52) | NOTUM | |
| SCHEMBL197671 | 0.72 | HSD11B1 (0.56) | HSD11B1TRPA1TRPM8TRPV1NOTUM | |
| SCHEMBL14387220 | 0.72 | SMARCA2 (0.66) | — | |
| SCHEMBL11349503 | 0.71 | HSD11B1 (0.50) | HSD11B1TRPA1TRPM8TRPV1BACE1 | |
| SCHEMBL9223899 | 0.70 | PLA2G7 (0.57) | HSD11B1TRPA1TRPM8TRPV1BACE1 | |
| SCHEMBL14879932 | 0.70 | HSD11B1 (0.46) | HSD11B1BACE1NOTUMPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353902-B1 | SUBSTITUTED PHENYLTRIAZOLOPYRIMIDINE HERBICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-05-05 | — | — | EP | disclosed |
| US-5127936-A | Substituted phenyltriazolopyrimidine herbicides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-07-07 | — | — | US | disclosed |
| WO-1990012012-A1 | SUBSTITUTED PHENYLTRIAZOLOPYRIMIDINE HERBICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-10-18 | — | — | WO | disclosed |
| EP-0353902-A1 | Substituted phenyltriazolopyrimidine herbicides | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-02-07 | — | — | EP | disclosed |