Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10445094 | 0.83 | PTGES (0.37) | ALOX5PTGESLMNAPTGS2 | |
| SCHEMBL9458804 | 0.78 | MDM2 (0.32) | MDM2 | |
| SCHEMBL9458995 | 0.71 | KMT2A (0.48) | KMT2AMEN1ALOX5KDM4EPTGES | |
| SCHEMBL17070911 | 0.66 | ALDH1A1 (0.40) | KMT2AMEN1KDM4ELMNACYP1A2 | |
| SCHEMBL10948857 | 0.66 | CSNK2B (0.48) | KMT2AMEN1ALOX5KDM4ELMNA | |
| SCHEMBL10951911 | 0.64 | KMT2A (0.45) | KMT2AMEN1ALOX5KDM4EPTGES | |
| SCHEMBL10957000 | 0.64 | KMT2A (0.45) | KMT2AMEN1ALOX5KDM4EPTGES | |
| SCHEMBL9458606 | 0.61 | ALOX5 (0.53) | KMT2AMEN1ALOX5PTGESPTGS2 | |
| SCHEMBL10946120 | 0.61 | KMT2A (0.50) | KMT2AMEN1ALOX5KDM4EPTGES | |
| SCHEMBL10954542 | 0.61 | KMT2A (0.50) | KMT2AMEN1ALOX5KDM4EPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397175-B1 | Substituted pyrrolizine compounds and theit use as pharmaceuticals | DANNHARDT GERD PROF DR (DE) | 1993-12-08 | — | — | EP | disclosed |
| EP-0397175-A1 | Substituted pyrrolizine compounds and theit use as pharmaceuticals | Dannhardt, Gerd, Prof.Dr. (DE) | 1990-11-14 | — | — | EP | disclosed |