Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | HRH1 | P35367 | 5/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.44 |
| ▸ | TACR2 | P21452 | 2/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.44 |
| ▸ | EED | O75530 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HLA-A | P04439 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10549840 | 0.89 | SLC6A9 (0.47) | KCNH2HRH1CYP2D6CHRM1CACNA1F | |
| SCHEMBL9535893 | 0.87 | HTR1A (0.53) | SSTR5KCNH2HRH1CYP2D6CHRM1 | |
| SCHEMBL9537922 | 0.86 | ALDH1A1 (0.38) | USP2LMNAHTR1AGAAMAPT | |
| SCHEMBL9383006 | 0.83 | SSTR5 (0.47) | SSTR5KCNH2HRH1CYP2D6CHRM1 | |
| SCHEMBL9536711 | 0.82 | CYP2D6 (0.59) | SSTR5KCNH2HRH1CYP2D6CHRM1 | |
| SCHEMBL9537833 | 0.82 | ALDH1A1 (0.39) | USP2HTR1AGAADRD2DRD4 | |
| SCHEMBL9801715 | 0.79 | SSTR5 (0.46) | SSTR5KCNH2HRH1CYP2D6CHRM1 | |
| SCHEMBL10551137 | 0.78 | DRD2 (0.52) | KCNH2HRH1CYP2D6CHRM1CACNA1F | |
| SCHEMBL10551226 | 0.78 | DRD2 (0.52) | KCNH2HRH1CYP2D6CHRM1CACNA1F | |
| SCHEMBL9537270 | 0.77 | SSTR5 (0.49) | SSTR5KCNH2HRH1CYP2D6CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | claimed |