Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.40 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.39 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9539903 | 0.76 | L3MBTL1 (0.42) | ADORA2AL3MBTL1ASIC3CHRNA7SMN1; SMN2 | |
| SCHEMBL18586016 | 0.73 | MPO (0.62) | ADORA2AMPOSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL9539943 | 0.72 | L3MBTL1 (0.50) | L3MBTL1ASIC3MBOAT4PNPHRH3 | |
| SCHEMBL9536206 | 0.72 | TXNRD1 (0.37) | ADORA2APNPGAASMN1; SMN2NPC1 | |
| SCHEMBL28488593 | 0.72 | P2RX3 (0.39) | SMN1; SMN2NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL9537122 | 0.71 | DHFR (0.43) | MPOALDH1A1CNR1CNR2 | |
| SCHEMBL2750449 | 0.69 | KDM4E (0.56) | L3MBTL1HRH3SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL16211565 | 0.69 | L3MBTL1 (0.53) | L3MBTL1ASIC3PNPHRH3SMN1; SMN2 | |
| SCHEMBL28497215 | 0.69 | KMT2A (0.40) | L3MBTL1ALDH1A1RAB9AKDM4E | |
| SCHEMBL23837621 | 0.68 | L3MBTL1 (0.42) | L3MBTL1ASIC3CHRNA7SMN1; SMN2PGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |