Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535707 | 0.78 | ALDH1A1 (0.48) | LMNAL3MBTL1CYP3A4CYP2C9RAB9A | |
| SCHEMBL9535561 | 0.77 | LMNA (0.44) | LMNAL3MBTL1RAB9ANPC1ALDH1A1 | |
| SCHEMBL9536889 | 0.77 | LMNA (0.44) | LMNAL3MBTL1RAB9ANPC1ALDH1A1 | |
| SCHEMBL9534491 | 0.77 | LMNA (0.44) | LMNAL3MBTL1RAB9ANPC1ALDH1A1 | |
| SCHEMBL9536661 | 0.75 | ALDH1A1 (0.44) | LMNAL3MBTL1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11779182 | 0.71 | THRB (0.67) | LMNAL3MBTL1GAARAB9ANPC1 | |
| SCHEMBL8945165 | 0.71 | RAB9A (0.41) | LMNAL3MBTL1RAB9ANPC1ALDH1A1 | |
| SCHEMBL8111879 | 0.69 | MAPT (0.43) | LMNAL3MBTL1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8945250 | 0.66 | ALDH1A1 (0.50) | LMNAL3MBTL1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4203830 | 0.66 | LMNA (0.60) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343752-B1 | Alkoxy-1,2,4-triazolo (1,5-c) pyrimidine-2-sulfonamides, process for their preparation and intermediates | DOWELANCO (US) | 1993-12-01 | — | — | EP | disclosed |
| US-5010195-A | From 5-alkoxy-1,2,4-triazolo(1,5-c)pyrimidine | THE DOW CHEMICAL COMPANY (US) | 1991-04-23 | — | — | US | disclosed |
| WO-1989011782-A1 | ALKOXY-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE-2-SULFONAMIDES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES | THE DOW CHEMICAL COMPANY (US) | 1989-12-14 | — | — | WO | disclosed |