Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.40 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.39 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535315 | 0.92 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4EUSP2TSHR | |
| SCHEMBL9537714 | 0.86 | ALDH1A1 (0.45) | ALDH1A1HSD17B10KDM4EUSP2TSHR | |
| Fumaric Acid SCHEMBL11015217 | 0.85 | TSHR (0.44) | ALDH1A1HSD17B10KDM4EUSP2TSHR | |
| Fumaric Acid SCHEMBL10818505 | 0.85 | TSHR (0.44) | ALDH1A1HSD17B10KDM4EUSP2TSHR | |
| SCHEMBL9537470 | 0.84 | KDM4E (0.50) | ALDH1A1HSD17B10KDM4EUSP2TSHR | |
| SCHEMBL9535185 | 0.82 | MAPT (0.49) | ALDH1A1HSD17B10KDM4EUSP2MEN1 | |
| SCHEMBL9539854 | 0.81 | ALDH1A1 (0.52) | ALDH1A1HSD17B10KDM4EUSP2TSHR | |
| SCHEMBL9536165 | 0.80 | CCR3 (0.56) | ALDH1A1HSD17B10KDM4EUSP2MEN1 | |
| SCHEMBL9535187 | 0.80 | ALDH1A1 (0.45) | ALDH1A1HSD17B10KDM4EUSP2TSHR | |
| SCHEMBL10550247 | 0.79 | MAPT (0.51) | ALDH1A1HSD17B10KDM4EUSP2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |