Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 18/20 | 0.47 |
| ▸ | PDCD1LG2 | Q9BQ51 | 15/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537485 | 0.89 | CD274 (0.47) | CD274PDCD1LG2ALDH1A1HPGDKDM4E | |
| SCHEMBL9536294 | 0.88 | CD274 (0.42) | CD274PDCD1LG2KDM4EPDCD1 | |
| SCHEMBL9536049 | 0.86 | KDM4E (0.49) | CD274PDCD1LG2ALDH1A1HPGDKDM4E | |
| SCHEMBL9534377 | 0.80 | MEN1 (0.42) | CD274PDCD1LG2ALDH1A1HPGDKDM4E | |
| SCHEMBL9537762 | 0.79 | KDM4E (0.49) | CD274PDCD1LG2ALDH1A1HPGDKDM4E | |
| SCHEMBL9533834 | 0.78 | ALDH1A1 (0.52) | CD274PDCD1LG2ALDH1A1HPGDKDM4E | |
| SCHEMBL10412730 | 0.76 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4E | |
| SCHEMBL9535997 | 0.73 | CD274 (0.39) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL27473924 | 0.70 | MAPT (0.47) | CD274PDCD1LG2ALDH1A1HPGDKDM4E | |
| SCHEMBL9534841 | 0.70 | MEN1 (0.41) | CD274PDCD1LG2ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532531-A1 | PHENOL AND PYRIDINOL DERIVATIVES AS PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |
| WO-1991017987-A1 | PHENOL AND PYRIDINOL DERIVATIVES AS PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-11-28 | — | — | WO | disclosed |