Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 15/20 | 0.42 |
| ▸ | PDCD1LG2 | Q9BQ51 | 12/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537527 | 0.88 | CD274 (0.47) | CD274PDCD1LG2PDCD1KDM4E | |
| SCHEMBL9535997 | 0.86 | CD274 (0.39) | CD274PDCD1LG2PDCD1BTKL3MBTL1 | |
| SCHEMBL9534377 | 0.81 | MEN1 (0.42) | CD274PDCD1LG2CDC25BKDM4EKMT2A | |
| SCHEMBL9538604 | 0.79 | CD274 (0.45) | CD274PDCD1LG2PDCD1CDC25BBTK | |
| SCHEMBL9537485 | 0.76 | CD274 (0.47) | CD274PDCD1LG2PDCD1KDM4E | |
| SCHEMBL9536629 | 0.74 | APAF1 (0.40) | CDC25BKDM4EKMT2A | |
| SCHEMBL9536049 | 0.73 | KDM4E (0.49) | CD274PDCD1LG2PDCD1KDM4EKMT2A | |
| SCHEMBL9533890 | 0.72 | CD274 (0.46) | CD274PDCD1LG2PDCD1CDC25BBTK | |
| SCHEMBL10412730 | 0.70 | ALDH1A1 (0.51) | CDC25BKDM4EKMT2A | |
| SCHEMBL27572668 | 0.70 | ALDH1A1 (0.44) | CDC25BCYP1A2KDM4EMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532531-A1 | PHENOL AND PYRIDINOL DERIVATIVES AS PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |
| WO-1991017987-A1 | PHENOL AND PYRIDINOL DERIVATIVES AS PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-11-28 | — | — | WO | disclosed |