Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1560475 | 0.85 | TDP1 (0.43) | TDP1TSHRALDH1A1HDAC8PABPC1 | |
| Betaine SCHEMBL8958531 | 0.84 | TSHR (0.39) | TSHRALDH1A1LMNAAPEX1PABPC1 | |
| Water SCHEMBL1913462 | 0.84 | TDP1 (0.42) | TDP1ALDH1A1HDAC8PABPC1EIF4H | |
| Betaine SCHEMBL1628919 | 0.83 | TSHR (0.42) | TSHRALDH1A1LMNAAPEX1ACHE | |
| SCHEMBL1560454 | 0.81 | TDP1 (0.42) | TDP1ALDH1A1HDAC8PABPC1EIF4H | |
| Betaine SCHEMBL8958510 | 0.80 | LMNA (0.40) | TSHRALDH1A1LMNAAPEX1PABPC1 | |
| Betaine SCHEMBL4654474 | 0.80 | TSHR (0.42) | TDP1TSHRALDH1A1LMNAAPEX1 | |
| Betaine SCHEMBL3421777 | 0.80 | TSHR (0.33) | TSHRALDH1A1LMNAAPEX1ACHE | |
| Water SCHEMBL8976375 | 0.80 | TDP1 (0.41) | TDP1ALDH1A1HDAC8PABPC1EIF4H | |
| Betaine SCHEMBL133669 | 0.79 | HDAC8 (0.35) | TSHRALDH1A1LMNAAPEX1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3802629-B1 | METHODS FOR REDUCING OR PREVENTING COLLOIDS ADHESION AND/OR FOULING ON A SUBSTRATE, COMPOSITIONS, AND COPOLYMERS USEFUL THEREFOR | SPECIALTY OPERATIONS FRANCE (FR) | 2024-05-01 | — | — | EP | claimed |
| CN-114364708-B | Method, composition and copolymer for use in the same for combating frost on a substrate | 罗地亚经营管理公司 | 2024-04-26 | — | — | CN | claimed |
| WO-2024003351-A1 | USE OF POLYMER ADDITIVE COMPRISING ZWITTERIONIC MOIETIES IN PVDF MEMBRANES FOR INCREASING THE FLUX OF SAID MEMBRANES | SOLVAY SA (BE) | 2024-01-04 | — | — | WO | claimed |
| WO-2024003352-A1 | USE OF POLYMER ADDITIVE COMPRISING ZWITTERIONIC MOIETIES IN PVDF MEMBRANES FOR DECREASING THE TRANSMEMBRANE PRESSURE AT CONSTANT FLUX OF SAID MEMBRANES | SOLVAY SA (BE) | 2024-01-04 | — | — | WO | claimed |
| CN-114072469-B | Use of polyphenol compounds and hydrophilic polymers for reducing or preventing colloidal adhesion and/or fouling on a substrate | 罗地亚经营管理公司 | 2023-06-06 | — | — | CN | claimed |
| CN-112237853-B | Antibacterial and anti-pollution microporous membrane and preparation method thereof | 浙江大学 | 2022-05-10 | — | — | CN | claimed |
| EP-3990556-A1 | USE OF POLYPHENOL COMPOUNDS AND HYDROPHILIC POLYMERS FOR REDUCING OR PREVENTING COLLOIDS ADHESION AND/OR FOULING ON A SUBSTRATE | RHODIA OPERATIONS (FR) | 2022-05-04 | — | — | EP | claimed |
| CN-114426633-A | Calcium salt-resistant and temperature-resistant tackifier and preparation method thereof | 中国石油化工股份有限公司 | 2022-05-03 | — | — | CN | claimed |
| WO-2021122628-A1 | POLYMER ADDITIVE COMPRISING ZWITTERIONIC MOIETIES FOR PVDF BASED MEMBRANES | SOLVAY SA (BE) | 2021-06-24 | — | — | WO | claimed |
| EP-3838387-A1 | POLYMER ADDITIVE COMPRISING ZWITTERIONIC MOIETIES FOR PVDF BASED MEMBRANES | Solvay SA (BE) | 2021-06-23 | — | — | EP | claimed |
| EP-2025743-B1 | Hard surface cleaning compostion | PROCTER & GAMBLE (US) | 2011-04-13 | — | — | EP | claimed |
| US-20110009309-A1 | Hard Surface Cleaning Composition | THE PROCTER & GAMBLE COMPANY | 2011-01-13 | — | — | US | claimed |
| EP-2272942-A1 | Hard surface cleaning composition | The Procter & Gamble Company (US) | 2011-01-12 | — | — | EP | claimed |
| US-20100210724-A1 | Method for modifying the properties of an aqueous suspension | RHODIA OPERATIONS (FR) | 2010-08-19 | — | — | US | claimed |
| WO-2010090738-A1 | METHOD FOR MODIFYING THE PROPERTIES OF AN AQUEOUS SUSPENSION | RHODIA OPERATIONS (FR) | 2010-08-12 | — | — | WO | claimed |
| US-20100197530-A1 | OIL FIELD TREATMENT FLUIDS WITH VISCOSIFIED BRINES | BAKER HUGHES HOLDINGS LLC | 2010-08-05 | — | — | US | claimed |
| US-20090197791-A1 | COPOLYMER CONTAINING ZWITTERIONIC UNITS AND OTHER UNITS, COMPOSITION COMPRISING THE COPOLYMER, AND USE | RHODIA RECHERCHES ET TECHNOLOGIES (FR) | 2009-08-06 | — | — | US | claimed |
| US-20090029895-A1 | HARD SURFACE CLEANING COMPOSITION | THE PROCTER & GAMBLE COMPANY | 2009-01-29 | — | — | US | claimed |
| US-20080045420-A1 | Zwitterionic Polymers Comprising Betaine-Type Units And Use Of Zwitterionic Polymers In Drilling Fluids | RHODIA CHIMIE (FR) | 2008-02-21 | — | — | US | claimed |
| US-20060217286-A1 | Composition for cleaning or rinsing hard surfaces | SPECIALTY OPERATIONS FRANCE (FR) | 2006-09-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210724-A1 | Method for modifying the properties of an aqueous suspension | APOB, HBB, SLC6A12 | TDP1 3217/4885TSHR 4176/4885ALDH1A1 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.