Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 8/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 4/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | GFER | P55789 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1745407 | 0.81 | MEN1 (0.60) | NPC1RAB9ASMN1; SMN2MAOAMAOB | |
| SCHEMBL9536253 | 0.77 | FDPS (0.45) | NPC1RAB9ASMN1; SMN2ALOX15HSD17B10 | |
| SCHEMBL9715445 | 0.75 | L3MBTL1 (0.49) | NPC1RAB9ASMN1; SMN2ALOX15HSD17B10 | |
| SCHEMBL11385164 | 0.75 | MEN1 (0.70) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7040902 | 0.74 | MAPT (0.59) | SMN1; SMN2ARTP53ALOX15HSD17B10 | |
| Oxalic Acid SCHEMBL9536045 | 0.74 | USP2 (0.57) | NPC1RAB9ASMN1; SMN2ALOX15HSD17B10 | |
| SCHEMBL9371263 | 0.71 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL9537766 | 0.71 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2ARTP53 | |
| SCHEMBL259707 | 0.70 | RAB9A (0.69) | NPC1RAB9ASMN1; SMN2ARMEN1 | |
| SCHEMBL11844280 | 0.70 | TDP1 (0.54) | SMN1; SMN2ALOX15HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |