Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL314557 | 0.76 | HTR2A (0.41) | MEN1KMT2ATP53LMNAKDM4E | |
| SCHEMBL6028210 | 0.74 | HTR2A (0.39) | MEN1KMT2ANPC1MTORTP53 | |
| SCHEMBL7740381 | 0.74 | TRPA1 (0.42) | TDP1HTR2ATRPA1 | |
| SCHEMBL3716502 | 0.71 | TRPA1 (0.40) | HTR2ATRPA1 | |
| SCHEMBL10909428 | 0.71 | RIPK1 (0.38) | NPC1MTORTP53CYP3A4CYP2D6 | |
| SCHEMBL555263 | 0.71 | HTR2A (0.48) | MEN1KMT2ANPC1CYP3A4CYP2D6 | |
| SCHEMBL17861719 | 0.71 | LMNA (0.40) | MEN1KMT2ANPC1MTORTP53 | |
| SCHEMBL11349841 | 0.69 | ALDH1A1 (0.46) | MEN1KMT2ACYP3A4CYP2C9MAPK1 | |
| SCHEMBL28037117 | 0.69 | NPC1 (0.38) | MEN1KMT2ANPC1MTORTP53 | |
| SCHEMBL315078 | 0.69 | HTR2A (0.41) | LMNATDP1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532693-A1 | 1,4-DIAMINO-2,3-DIHYDROXYBUTANES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-03-24 | — | — | EP | disclosed |