Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT3 | O60678 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536547 | 0.88 | SSTR5 (0.52) | SSTR5 | |
| SCHEMBL9537882 | 0.87 | SLC6A9 (0.41) | SLC6A9GRM2SSTR5CYP2D6HRH1 | |
| SCHEMBL9536663 | 0.86 | RAB9A (0.55) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL9537085 | 0.85 | SLC6A9 (0.58) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL9537962 | 0.84 | HTR1A (0.57) | SSTR5CYP2D6HRH1KCNH2CHRM1 | |
| SCHEMBL10804293 | 0.83 | KCNH2 (0.47) | SLC6A9GRM2CYP2D6HRH1KCNH2 | |
| SCHEMBL9536078 | 0.82 | KCNH2 (0.50) | CYP2D6HRH1KCNH2CHRM1 | |
| Oxalic Acid SCHEMBL10802671 | 0.82 | GRIN2B (0.41) | SLC6A9SSTR5 | |
| Oxalic Acid SCHEMBL9538513 | 0.82 | GRIN2B (0.41) | SLC6A9SSTR5 | |
| Oxalic Acid SCHEMBL9538518 | 0.82 | GRIN2B (0.41) | SLC6A9SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |