Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9539076 | 0.91 | P2RX7 (0.46) | P2RX7LMNAHTR7MEN1NR1I2 | |
| SCHEMBL10551946 | 0.90 | TSHR (0.52) | LMNAHTR7MEN1CYP1A2CYP3A4 | |
| SCHEMBL9537087 | 0.87 | TSHR (0.54) | LMNAHTR7MEN1CYP1A2CYP3A4 | |
| SCHEMBL9537714 | 0.82 | ALDH1A1 (0.45) | MEN1DRD2DRD3KMT2AUSP2 | |
| SCHEMBL9540587 | 0.82 | TSHR (0.50) | MEN1ADRA1AKMT2AADRA1DMAPK1 | |
| SCHEMBL9540318 | 0.81 | TSHR (0.41) | MEN1HRH1KMT2AUSP2MAPK1 | |
| SCHEMBL9537470 | 0.81 | KDM4E (0.50) | CYP2D6DRD2HRH1OPRM1DRD3 | |
| SCHEMBL9535315 | 0.81 | ALDH1A1 (0.47) | MEN1CYP1A2CYP2D6DRD2DRD3 | |
| SCHEMBL9535911 | 0.81 | ALDH1A1 (0.43) | LMNADRD2DRD3KCNH2USP2 | |
| SCHEMBL9539277 | 0.81 | ALDH1A1 (0.49) | MEN1CYP1A2CYP3A4CYP2D6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |