Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 3/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537087 | 0.83 | TSHR (0.54) | TSHRALDH1A1MAPTMAPK1NPSR1 | |
| SCHEMBL9537470 | 0.82 | KDM4E (0.50) | TSHRALDH1A1KDM4EUSP2HSD17B10 | |
| SCHEMBL9535315 | 0.82 | ALDH1A1 (0.47) | TSHRALDH1A1KDM4EUSP2HSD17B10 | |
| SCHEMBL9538853 | 0.81 | P2RX7 (0.49) | USP2MAPK1HRH1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9537429 | 0.81 | GAA (0.52) | TSHRALDH1A1KDM4EUSP2HSD17B10 | |
| SCHEMBL9539277 | 0.80 | ALDH1A1 (0.49) | TSHRALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL9537714 | 0.80 | ALDH1A1 (0.45) | TSHRALDH1A1KDM4EUSP2HSD17B10 | |
| SCHEMBL9539854 | 0.80 | ALDH1A1 (0.52) | TSHRALDH1A1KDM4EUSP2HSD17B10 | |
| SCHEMBL10551946 | 0.79 | TSHR (0.52) | TSHRALDH1A1HSD17B10MAPTMAPK1 | |
| SCHEMBL9535911 | 0.79 | ALDH1A1 (0.43) | TSHRALDH1A1KDM4EUSP2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | claimed |