Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CCR4 | P51679 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916278 | 0.89 | KDM4E (0.49) | KDM4ETSHRCASP1CASP7BRD4 | |
| SCHEMBL9539659 | 0.81 | ROCK2 (0.46) | KDM4ETSHRCASP1CASP7BRD4 | |
| SCHEMBL8842866 | 0.80 | KDM4E (0.57) | KDM4ETSHRCASP1CASP7BRD4 | |
| SCHEMBL8914173 | 0.78 | MAPK1 (0.53) | KDM4ETSHRCASP1CASP7BRD4 | |
| SCHEMBL5062486 | 0.78 | HTT (0.53) | KDM4ETSHRCASP1CASP7BRD4 | |
| SCHEMBL3727147 | 0.78 | MMP8 (0.58) | KDM4ETSHRCASP1CASP7LMNA | |
| SCHEMBL9540915 | 0.77 | MMP2 (0.54) | TSHRLMNAHTT | |
| SCHEMBL2705837 | 0.76 | HCRTR1 (0.64) | KDM4ETSHRCASP1CASP7BRD4 | |
| SCHEMBL7359593 | 0.76 | MMP8 (0.55) | KDM4ETSHRCASP1CASP7BRD4 | |
| SCHEMBL2706418 | 0.76 | HCRTR1 (0.64) | KDM4ETSHRCASP1CASP7BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993005014-A1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO-WEDROPHARM GMBH (DE) | 1993-03-18 | — | — | WO | disclosed |