SCHEMBL9541310

SCHEMBL9541310

NN1C(=O)NC(=O)C1c1cccc2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 3/20 0.50
MTNR1A P48039 1/20 0.43
KDM1A O60341 1/20 0.42
MAPT P10636 3/20 0.42
KDM4E B2RXH2 2/20 0.42
HPGD P15428 2/20 0.42
ALDH1A1 P00352 2/20 0.42
TDP2 O95551 1/20 0.42
ALOX12 P18054 1/20 0.42
MAPK1 P28482 1/20 0.42
CASP3 P42574 1/20 0.42
HTT P42858 1/20 0.42
GALK1 P51570 1/20 0.42
BLM P54132 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
SENP8 Q96LD8 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
SENP6 Q9GZR1 1/20 0.42
KDM4C Q9H3R0 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6380847 0.74 IDO1 (0.54) IDO1MTNR1AKDM1AMAPTKDM4E
SCHEMBL18025752 0.71 IDO1 (0.51) IDO1MTNR1AKDM1AMAPTKDM4E
SCHEMBL10822158 0.68 IDO1 (0.55) IDO1MTNR1AKDM1AMAPTKDM4E
SCHEMBL30588975 0.68 IDO1 (0.55) IDO1MTNR1AKDM1AMAPTKDM4E
SCHEMBL6289027 0.67 IDO1 (0.41) IDO1MTNR1AMAPTKDM4EHPGD
SCHEMBL9387969 0.67 IDO1 (1.00) IDO1MTNR1AMAPTHTTSMN1; SMN2
SCHEMBL11039068 0.67 CA2 (0.54) IDO1MTNR1AKDM1AMAPTKDM4E
SCHEMBL24017027 0.66 MTNR1A (0.49) IDO1MTNR1AKDM1AMAPTKDM4E
SCHEMBL2358320 0.66 MAPT (0.56) IDO1MTNR1AKDM1AMAPTKDM4E
SCHEMBL29462549 0.66 MAPT (0.56) IDO1MTNR1AKDM1AMAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993013092-A1 IMIDAZOLIDINEDIONE DERIVATIVES SARGES REINHARD (US) 1993-07-08 WO claimed
US-5011840-A Imidazolidinedione derivatives in diabetes treatment PFIZER INC. (US) 1991-04-30 US claimed
EP-0269355-B1 IMIDAZOLIDINEDIONE DERIVATIVES PFIZER INC. (US) 1991-04-10 EP claimed
EP-0269355-A1 Imidazolidinedione derivatives PFIZER INC. (US) 1988-06-01 EP claimed
WO-1993013092-A1 IMIDAZOLIDINEDIONE DERIVATIVES SARGES REINHARD (US) 1993-07-08 WO disclosed
WO-1993013092-A1 IMIDAZOLIDINEDIONE DERIVATIVES SARGES REINHARD (US) 1993-07-08 WO disclosed
US-5011840-A Imidazolidinedione derivatives in diabetes treatment PFIZER INC. (US) 1991-04-30 US disclosed
US-5011840-A Imidazolidinedione derivatives in diabetes treatment PFIZER INC. (US) 1991-04-30 US disclosed
EP-0269355-B1 IMIDAZOLIDINEDIONE DERIVATIVES PFIZER INC. (US) 1991-04-10 EP disclosed
EP-0269355-A1 Imidazolidinedione derivatives PFIZER INC. (US) 1988-06-01 EP disclosed