Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9542254 | 0.83 | TRPM8 (0.55) | TRPM8NPC1RAB9AHPGDTSHR | |
| SCHEMBL9543513 | 0.79 | HIF1A (0.43) | NPC1RAB9ATSHR | |
| SCHEMBL10453097 | 0.78 | SLC6A9 (0.51) | TRPM8NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL9542307 | 0.76 | MEN1 (0.42) | TSHRMEN1ALDH1A1KMT2ATP53 | |
| SCHEMBL9544578 | 0.76 | TRPM8 (0.47) | TRPM8NPC1RAB9AHPGDTSHR | |
| SCHEMBL9544541 | 0.74 | TRPM8 (0.46) | TRPM8NPC1RAB9AHPGDTSHR | |
| SCHEMBL9543538 | 0.72 | NPC1 (0.45) | TRPM8NPC1RAB9AHPGDTSHR | |
| SCHEMBL12917871 | 0.72 | ALDH1A1 (0.58) | NPC1RAB9AHPGDTSHRMEN1 | |
| SCHEMBL9540784 | 0.72 | MEN1 (0.47) | TRPM8RAB9AKDM4EMEN1ALDH1A1 | |
| SCHEMBL14407204 | 0.72 | PDK2 (0.45) | TRPM8KDM4EMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5223539-A | Antagonist of platelet activating factor | G. D. SEARLE & CO. (US) | 1993-06-29 | — | — | US | disclosed |
| WO-1993010077-A1 | N,N-DI-ALKYL(PHENOXY)BENZAMIDE DERIVATIVES | G.D. SEARLE & CO. (US) | 1993-05-27 | — | — | WO | disclosed |