Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 1/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.34 |
| ▸ | CPA1 | P15085 | 1/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9548280 | 0.81 | NOTUM (0.40) | LMNAALDH1A1PTGS2EPHX2RAB9A | |
| Hydrochloric Acid SCHEMBL9548294 | 0.77 | EPHX2 (0.36) | LMNAALDH1A1EPHX2RAB9AHPGD | |
| SCHEMBL442507 | 0.70 | NOTUM (0.43) | LMNAALDH1A1EPHX2RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL19555684 | 0.69 | NOTUM (0.42) | LMNAALDH1A1EPHX2RAB9ASMN1; SMN2 | |
| SCHEMBL9548321 | 0.69 | PPARA (0.42) | SHMT1SHMT2ALDH1A1RAB9AHPGD | |
| SCHEMBL6408017 | 0.66 | SMN1; SMN2 (0.53) | LMNAEPHX2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4009260 | 0.65 | RAB9A (0.44) | ALDH1A1MAPTRAB9AHPGDSMN1; SMN2 | |
| SCHEMBL5520474 | 0.65 | LMNA (0.47) | LMNAALDH1A1MAPTEPHX2RAB9A | |
| (Isobutyrylamino)Acetic Acid SCHEMBL622544 | 0.64 | ALDH1A1 (0.67) | LMNAALDH1A1MAPTPTGS2TDP1 | |
| Muscimol SCHEMBL770913 | 0.64 | NOTUM (0.41) | LMNAALDH1A1RAB9AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5273989-A | 3,5-disubstituted 2-isoxazolines and isoxazoles, agents containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | claimed |
| EP-0451790-A1 | 3,5-disubstituted 2-isoxazolines and isoxazoles, process for their preparation, medicines containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-16 | — | — | EP | claimed |
| US-5273989-A | 3,5-disubstituted 2-isoxazolines and isoxazoles, agents containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |
| EP-0451790-A1 | 3,5-disubstituted 2-isoxazolines and isoxazoles, process for their preparation, medicines containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-16 | — | — | EP | disclosed |