Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADA | P00813 | 1/20 | 0.56 |
| ▸ | PI4K2A | Q9BTU6 | 6/20 | 0.56 |
| ▸ | PI4KA | P42356 | 5/20 | 0.55 |
| ▸ | PI4K2B | Q8TCG2 | 5/20 | 0.55 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.53 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22990449 | 0.87 | P2RY1 (0.54) | ADAPI4K2AADORA1 | |
| SCHEMBL20324651 | 0.87 | TAS1R3 (0.47) | ADAPI4K2API4KAPI4K2BPI4KB | |
| SCHEMBL21637073 | 0.87 | PI4K2A (0.46) | ADAPI4K2API4KAPI4K2BPI4KB | |
| SCHEMBL24695057 | 0.86 | ADA (0.54) | ADAPI4K2API4KAPI4K2BPI4KB | |
| SCHEMBL10083618 | 0.85 | PI4K2A (0.40) | ADAPI4K2API4KAPI4K2BPI4KB | |
| SCHEMBL9548820 | 0.84 | AHCY (0.49) | ADAPI4K2ATP53PRMT5WDR77 | |
| SCHEMBL12060727 | 0.83 | ADA (0.51) | ADAPI4K2API4KAPI4K2BPI4KB | |
| SCHEMBL9153371 | 0.83 | ADA (0.51) | ADAPI4K2API4KAPI4K2BPI4KB | |
| SCHEMBL9153368 | 0.83 | ADA (0.51) | ADAPI4K2API4KAPI4K2BPI4KB | |
| SCHEMBL9548808 | 0.83 | ADA (0.51) | ADAPI4K2API4KAPI4K2BPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120034184-A1 | 4'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION | DEVOS RENE ROBERT (GB) | 2012-02-09 | — | — | US | disclosed |
| US-8071567-B2 | 4′-substituted nucleoside derivatives as inhibitors of HCV RNA replication | ROCHE PALO ALTO LLC (US) | 2011-12-06 | — | — | US | disclosed |
| US-20100003213-A1 | 4'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION | DEVOS RENE ROBERT | 2010-01-07 | — | — | US | disclosed |
| US-5192749-A | Viricide, AIDS | SYNTEX (U.S.A.) INC. (US) | 1993-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003213-A1 | 4'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION | NSUN2, RNGTT, RNMT | ADA 198/4885PI4K2A 2183/4885PI4KA 1316/4885 |
| US-20120034184-A1 | 4'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION | NSUN2, RNGTT, RNMT | ADA 123/4885PI4K2A 2564/4885PI4KA 2246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.