Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95406 | 0.78 | PDK1 (0.59) | NPC1RAB9APDK1PDK2PDK3 | |
| SCHEMBL2733296 | 0.77 | CETP (0.61) | HDAC1HDAC2HDAC3MAPK1HDAC10 | |
| SCHEMBL15711989 | 0.77 | HDAC1 (0.55) | HDAC1HDAC2HDAC3MAPK1HDAC10 | |
| SCHEMBL12427249 | 0.74 | PTGS1 (0.55) | HDAC1HDAC2HDAC3MAPK1HDAC10 | |
| SCHEMBL94957 | 0.74 | GLA (0.37) | NPC1RAB9APDK1PDK2PDK3 | |
| SCHEMBL12963094 | 0.72 | LMNA (0.57) | HDAC1HDAC2HDAC3MAPK1HDAC10 | |
| SCHEMBL8909870 | 0.71 | PTGS1 (0.55) | HDAC1HDAC2HDAC3MAPK1HDAC10 | |
| SCHEMBL3846828 | 0.71 | PTGS1 (0.58) | HDAC1HDAC2HDAC3MAPK1HDAC10 | |
| SCHEMBL8910665 | 0.68 | PTGS1 (0.55) | HDAC1HDAC2HDAC3MAPK1HDAC10 | |
| SCHEMBL463597 | 0.68 | ALDH1A1 (0.61) | HDAC1HDAC2HDAC3MAPK1HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058085-A1 | Deuterium Modified Benzimidazoles | CONCERT PHARMACEUTICALS, INC. | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058085-A1 | Deuterium Modified Benzimidazoles | POLRMT, EIF2AK2, DUT | HDAC1 195/4885HDAC2 284/4885HDAC3 337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.