Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGT1 | P19440 | 2/20 | 0.55 |
| ▸ | REN | P00797 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.52 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.51 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.51 |
| ▸ | ITGAL | P20701 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CPA1 | P15085 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | ECE1 | P42892 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16673595 | 0.84 | AGTR2 (0.58) | RENCYP3A4SLC7A5AGTR2ITGB2 | |
| SCHEMBL3599440 | 0.84 | AGTR2 (0.57) | GGT1RENCYP3A4SLC7A5AGTR2 | |
| SCHEMBL5907039 | 0.84 | AGTR2 (0.57) | GGT1RENCYP3A4SLC7A5AGTR2 | |
| SCHEMBL28133942 | 0.83 | REN (0.60) | RENCYP3A4SLC7A5AGTR2ITGB2 | |
| SCHEMBL29971719 | 0.83 | REN (0.60) | RENCYP3A4SLC7A5AGTR2ITGB2 | |
| SCHEMBL8250332 | 0.82 | AGTR2 (0.61) | RENCYP3A4SLC7A5AGTR2ITGB2 | |
| SCHEMBL5869520 | 0.82 | AGTR2 (0.61) | RENCYP3A4SLC7A5AGTR2ITGB2 | |
| SCHEMBL1667212 | 0.81 | ALDH1A1 (0.54) | CYP3A4ITGB2ICAM1ITGALALDH1A1 | |
| SCHEMBL30184773 | 0.81 | AGTR2 (0.60) | RENCYP3A4SLC7A5AGTR2ITGB2 | |
| SCHEMBL27826956 | 0.81 | AGTR2 (0.60) | RENCYP3A4SLC7A5AGTR2ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250517-A | Hypotensive and cardiotonic agents; cardiac insufficiency | HOFFMANN-LA ROCHE INC. (US) | 1993-10-05 | — | — | US | disclosed |