Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.49 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9559731 | 0.91 | THRB (0.59) | THRBLMNAUSP2L3MBTL1KCNH2 | |
| SCHEMBL9559661 | 0.90 | TP53 (0.51) | LMNAUSP2KCNH2TP53MAPT | |
| SCHEMBL9559726 | 0.86 | DRD2 (0.50) | LMNATP53MEN1KMT2AADORA2B | |
| SCHEMBL9559630 | 0.81 | TP53 (0.56) | LMNAUSP2KCNH2TP53MAPT | |
| SCHEMBL9559576 | 0.78 | HTR2A (0.61) | LMNAUSP2TP53MAPTHTR4 | |
| SCHEMBL9559709 | 0.78 | DRD2 (0.55) | LMNAKCNH2TP53MEN1KMT2A | |
| SCHEMBL5654244 | 0.78 | L3MBTL1 (0.75) | THRBL3MBTL1KCNH2MAPTMEN1 | |
| SCHEMBL11172796 | 0.77 | HTR2A (0.57) | THRBLMNAUSP2L3MBTL1KCNH2 | |
| SCHEMBL9559698 | 0.76 | DRD2 (0.62) | TP53MEN1KMT2ACACNA1GDRD2 | |
| SCHEMBL9559605 | 0.76 | TP53 (0.57) | LMNAKCNH2TP53MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544765-A1 | PIPERAZINYL DERIVATIVES. | NOVO NORDISK AS (DK) | 1993-06-09 | — | — | EP | claimed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | claimed |
| US-5246935-A | Cardiovascular and gastrointestinal | NOVO NORDISK A/S (DK) | 1993-09-21 | — | — | US | disclosed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | disclosed |