SCHEMBL9560419

SCHEMBL9560419

COCc1ccc(C(Cl)(COCc2cccc(Oc3ccccc3)c2)C(F)(F)F)cc1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.39
ALDH1A1 P00352 3/20 0.39
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
FFAR1 O14842 3/20 0.37
FFAR4 Q5NUL3 2/20 0.37
CETP P11597 3/20 0.36
TDP1 Q9NUW8 2/20 0.36
LMNA P02545 1/20 0.36
ADRA2A P08913 1/20 0.36
CNR1 P21554 1/20 0.36
ATM Q13315 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
CHRM3 P20309 1/20 0.35
TACR1 P25103 1/20 0.34
MAPK14 Q16539 2/20 0.34
FAAH O00519 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9560778 0.93 ALDH1A1 (0.39) KDM4EALDH1A1HTTSMN1; SMN2FFAR1
SCHEMBL9560366 0.90 KDM4E (0.48) KDM4EALDH1A1HTTSMN1; SMN2FFAR1
SCHEMBL9560352 0.89 FFAR1 (0.42) KDM4EALDH1A1HTTSMN1; SMN2FFAR1
SCHEMBL9560713 0.86 LTA4H (0.46) KDM4EALDH1A1HTTSMN1; SMN2FFAR1
SCHEMBL9560464 0.85 MAPK14 (0.47) FFAR1FFAR4CETPTACR1MAPK14
SCHEMBL9560674 0.84 CETP (0.39) KDM4EALDH1A1HTTSMN1; SMN2FFAR1
SCHEMBL10854563 0.83 KDM4E (0.44) KDM4EALDH1A1HTTSMN1; SMN2FFAR1
SCHEMBL9561530 0.81 CETP (0.39) KDM4EALDH1A1FFAR1FFAR4CETP
SCHEMBL9561537 0.81 CETP (0.39) KDM4EALDH1A1FFAR1FFAR4CETP
SCHEMBL9560848 0.80 ALDH1A1 (0.42) ALDH1A1HTTSMN1; SMN2FFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5225607-A Multistage etherification or dehydrohalogenation and reductive dechlorination IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-07-06 US disclosed
US-5196610-A INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-03-23 US disclosed
EP-0211561-B1 INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-03-11 EP disclosed
EP-0211561-A1 Insecticidal ethers IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-02-25 EP disclosed