SCHEMBL9560466

SCHEMBL9560466

COc1ccc(C(O)(COCc2cccc(Oc3ccccc3)c2)C(F)(F)F)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
KDM4E B2RXH2 2/20 0.48
HTT P42858 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
LMNA P02545 2/20 0.44
MAPT P10636 2/20 0.44
TP53 P04637 1/20 0.44
CETP P11597 2/20 0.43
CHRM3 P20309 3/20 0.41
NR1H2 P55055 1/20 0.41
NR1H3 Q13133 1/20 0.41
LTA4H P09960 1/20 0.41
PGR P06401 1/20 0.40
FFAR1 O14842 2/20 0.40
FFAR4 Q5NUL3 1/20 0.40
FAAH O00519 1/20 0.39
MAPK14 Q16539 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2E1 P05181 1/20 0.39
CYP3A4 P08684 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9560674 0.90 CETP (0.39) ALDH1A1KDM4EHTTSMN1; SMN2LMNA
SCHEMBL9560435 0.90 FFAR1 (0.45) LMNACETPFFAR1FFAR4FAAH
SCHEMBL9561097 0.90 MAPK14 (0.44) CETPLTA4HFFAR1FFAR4MAPK14
SCHEMBL9560412 0.89 LTA4H (0.46) SMN1; SMN2LMNAMAPTTP53CETP
SCHEMBL9560889 0.89 MAPK14 (0.49) CETPLTA4HFFAR1FFAR4MAPK14
SCHEMBL9560878 0.85 LMNA (0.41) ALDH1A1KDM4EHTTSMN1; SMN2LMNA
SCHEMBL9560366 0.84 KDM4E (0.48) ALDH1A1KDM4EHTTSMN1; SMN2LMNA
SCHEMBL9560407 0.84 LMNA (0.40) ALDH1A1KDM4EHTTSMN1; SMN2LMNA
SCHEMBL9339448 0.83 KDM4E (0.54) ALDH1A1KDM4EHTTSMN1; SMN2CETP
SCHEMBL9561343 0.82 CETP (0.41) CETPFFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5225607-A Multistage etherification or dehydrohalogenation and reductive dechlorination IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-07-06 US disclosed
US-5196610-A INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-03-23 US disclosed
EP-0211561-B1 INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-03-11 EP disclosed
EP-0211561-A1 Insecticidal ethers IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-02-25 EP disclosed