SCHEMBL9560922

SCHEMBL9560922

CC[S+]([O-])c1nc2ccccc2[nH]1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DDAH1 O94760 1/20 0.51
KDM4E B2RXH2 2/20 0.46
LMNA P02545 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C19 P33261 1/20 0.46
NPC1 O15118 2/20 0.46
ALDH1A1 P00352 2/20 0.46
RAB9A P51151 2/20 0.46
PKM P14618 2/20 0.46
ABCB11 O95342 1/20 0.46
TP53 P04637 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
HSD17B10 Q99714 1/20 0.46
TXN P10599 1/20 0.45
POLB P06746 1/20 0.43
BCHE P06276 2/20 0.43
TRPC3 Q13507 1/20 0.43
TRPC4 Q9UBN4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9439979 0.84 DDAH1 (0.43) DDAH1KDM4ELMNACYP1A2CYP2D6
SCHEMBL7289165 0.83 NPC1 (0.46) DDAH1KDM4ENPC1ALDH1A1RAB9A
SCHEMBL7289169 0.83 RAB9A (0.46) DDAH1KDM4ENPC1ALDH1A1RAB9A
SCHEMBL9422145 0.82 DDAH1 (0.47) DDAH1KDM4ELMNACYP1A2CYP2D6
SCHEMBL28468886 0.81 SMN1; SMN2 (0.46) DDAH1KDM4ELMNANPC1ALDH1A1
SCHEMBL2799383 0.80 ALDH1A1 (0.50) DDAH1KDM4ELMNACYP1A2CYP2D6
SCHEMBL636639 0.80 GAA (0.50) DDAH1KDM4ENPC1ALDH1A1RAB9A
SCHEMBL7288161 0.80 EPHX2 (0.46) DDAH1KDM4ENPC1ALDH1A1RAB9A
SCHEMBL7288152 0.80 NPC1 (0.43) DDAH1KDM4ENPC1ALDH1A1RAB9A
SCHEMBL7353284 0.80 DDAH1 (0.41) DDAH1KDM4ELMNACYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0548103-A1 USE OF PYRIDYLMETHYLSULPHINYL-1H-BENZIMIDAZOLE DERIVATES IN THE TREATMENT OF ILLNESSES CAUSED BY HELICOBACTER BACTERIA BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1993-06-30 EP disclosed
WO-1992004898-A1 USE OF PYRIDYLMETHYLSULPHINYL-1H-BENZIMIDAZOLE DERIVATES IN THE TREATMENT OF ILLNESSES CAUSED BY HELICOBACTER BACTERIA BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1992-04-02 WO disclosed