Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9422419 | 0.77 | HIF1A (0.49) | HIF1AKDM4EMAPK1ATMEPHX2 | |
| SCHEMBL9564344 | 0.72 | NPC1 (0.40) | MAPK1ATMEPHX2PTGS2TDP1 | |
| SCHEMBL9564368 | 0.72 | HIF1A (0.44) | HIF1AKDM4EMAPK1ATMEPHX2 | |
| SCHEMBL9564402 | 0.70 | VCP (0.49) | HIF1AKDM4EATMMLLT1RAB9A | |
| SCHEMBL9564390 | 0.69 | KDM4E (0.41) | HIF1AKDM4EMAPK1ATMMLLT1 | |
| SCHEMBL9564361 | 0.68 | RAB9A (0.49) | HIF1AEPHX2MAPTHPGDL3MBTL1 | |
| SCHEMBL13096156 | 0.67 | HIF1A (0.50) | HIF1AKDM4EMAPK1ATMEPHX2 | |
| SCHEMBL10874711 | 0.63 | EPHX2 (0.63) | HIF1AMAPK1EPHX2TRPV1HDAC4 | |
| SCHEMBL17652584 | 0.63 | HIF1A (0.77) | HIF1AKDM4EMAPK1ATMMLLT1 | |
| SCHEMBL15105013 | 0.63 | EPHX2 (0.37) | EPHX2TRPV1TDP1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563686-A1 | Utilization of 3 substituted amino isoxazole derivatives against endoparasites, new 3 substituted amino isoxazols and process for their preparation | BAYER AG (DE) | 1993-10-06 | — | — | EP | disclosed |